Wednesday, 20 October 2021

A newly designed vaccine may eradicate polio once and for all

LONDON: Public health organisations around the world have been fighting for the global eradication of polio since 1988. Through massive vaccination efforts, the incidence of polio has gone down 99% since then, with the virus eradicated from most of the countries on Earth.

But there have been many setbacks.

One particularly serious threat has surfaced over the last 15 years. Among poorly vaccinated populations, an increasing number of polio cases are due to strains of the virus that originated from one version of the vaccine itself. The Sabin vaccine, which is taken orally, is composed of live but weakened viruses that won’t sicken recipients but will still create lasting immunity against polio.

However, through genetic changes, the weakened vaccine virus can reacquire the ability to cause paralytic polio. How this happens and how to prevent it are under active research. A new vaccine deliberately constructed to prevent the poliovirus from regaining virulence may be the answer.

One particularly serious threat has surfaced over the last 15 years. Among poorly vaccinated populations, an increasing number of polio cases are due to strains of the virus that originated from one version of the vaccine itself. The Sabin vaccine, which is taken orally, is composed of live but weakened viruses that won’t sicken recipients but will still create lasting immunity against polio.

However, through genetic changes, the weakened vaccine virus can reacquire the ability to cause paralytic polio. How this happens and how to prevent it are under active research. A new vaccine deliberately constructed to prevent the poliovirus from regaining virulence may be the answer.

Virus in vaccines

The virus that causes polio infects the cells of the throat and intestine. People usually catch it by ingesting food or water contaminated with faecal matter from an infected person.

Most people infected with the poliovirus have no symptoms at all; about a quarter of infections result in flu-like symptoms. However, in about 1 out of every 200 cases, the virus invades the cells of the central nervous system, causing paralysis.

Poliovirus is a very simple virus. It is composed of a shell, or capsule, made of protein. Inside the capsule is a single strand of ribonucleic acid, or RNA, that encodes the genetic information to make new virus particles. There are three poliovirus strains – PV1, PV2 and PV3. Immunity to one strain does not confer immunity to the other two, so both the original Salk and Sabin vaccines included all three.

The Salk vaccine, which is injected, is composed of killed viruses; the Sabin vaccine, taken orally, contains live but weakened viruses. Such weakened vaccine viruses are known as attenuated. The oral vaccine is both more effective and easier to administer than the injected vaccine and so it has been the primary weapon for the worldwide eradication of polio.

Once a child is immunised with the oral polio vaccine, the weakened virus lives in their intestine for several weeks, allowing the child to develop immunity by building up antibodies. During this time, recipients shed live viruses in their faeces. The weakened viruses in the vaccine itself do not cause polio and this shedding can help to immunise unvaccinated people that come into close contact with recently vaccinated individuals.

But shortly after the oral vaccine became widely used in the early 1960s, researchers discovered that some shed viruses had reacquired the ability to cause paralysis.

As the viruses multiply in the intestine, they undergo genetic changes, some of which can reverse or circumvent the original genetic changes that had made them less virulent. These vaccine-derived virulent viruses very rarely cause their vaccinated host to get polio, but, when they circulate in the population, they put unvaccinated individuals at grave risk.

Because of this risk, most developed countries, including the United States, have stopped using the oral Sabin vaccine, relying instead on several injections of the Salk vaccine. However, the oral polio vaccine is still the most available, and reliable, vaccine in developing countries.

Fine-tuning efforts

One of the polio strains – type 2 polio, or PV2 – was declared eradicated worldwide in 2015. The challenge then became preventing new cases of type 2 polio that could stem from virus shed by newly vaccinated people.

To prevent these new cases of vaccine-derived type 2 polio, the World Health Organisation campaigned to replace the standard oral polio vaccine with one consisting of only PV1 and PV3. This switch was completed in 2016.

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