LEEDS: After half-centuries from Joe Root (84) and Eoin Morgan (76) had helped England post 351-9 from their 50 overs, Woakes (5-54) ripped through the Pakistan top order in a fine opening burst.
He took three wickets without conceding a run in his first two overs to leave the tourists 6-3 before returning late on to take another two wickets as Pakistan, for whom Sarfaraz Ahmed (97) and Babar Azam (80) provided the only sustained resistance, were bowled out for 297.
With the series won, England have just two warm-ups games left before the World Cup with the final 15-man squad to be announced on Tuesday. Morgan chose to bat first in preparation for the World Cup and he could not have wished for a better start as England raced to three figures inside 11 overs.
Pakistan faced their second consecutive ODI series sweep for as they were also defeated 5-0 by Australia in UAE ahead of World Cup.